Development of breast cancer involves genetic, hormonal and environmental factors. Two major genes known to confer susceptibility are BRCA 1 and BRCA 2, explain only 5-10% of the total incidence. The other genes which are related to hormone exposure and also plausible candidates for susceptibility include estrogen receptor, progesterone receptor and vitamin D receptor which are members of nuclear receptor superfamily. ICPO intends to, therefore, perform the studies of mutation and polymorphism of Genes like ER, CYP17, AR, Vitamin D Receptor, BRCA1, BRCA2, p53, p16, Her2-Neu to establish any propensity of occurrence of certain mutation in ethnic groups which renders the North-East population more susceptible to the development of breast cancer.
Thence, Aaroogya conducted awareness and screening sessions for Breast Cancer in inaccessible lands like Village Pongtung near Dawki in Meghalaya. Pongtung village is located in Pynursla Tehsil of East Khasi Hills district in Meghalaya, India. It is situated 15km away from sub-district headquarter Pynursla and 61km away from district headquarter Shillong.Pongtung has a total population of 579 peoples. 276 are males while 303 are females as per Population Census 2011.
In Pongtung village population of children with age 0-6 is 115 which makes up 19.86 % of total population of the village. Average Sex Ratio of Pongtung village is 1098 which is higher than Meghalaya state average of 989. Child Sex Ratio for the Pongtung as per census is 1170, higher than Meghalaya average of 970. Pongtung village has higher literacy rate compared to Meghalaya. In 2011, la iteracy rate of Pongtung village was 78.45 % compared to 74.43 % of Meghalaya.